The August issue of Nature Biotechnology highlighted our latest work on the cover. We show that deep learning architecture can discover the binding specificities of DNA and RNA-binding proteins from raw sequences. By accurately modelling how proteins bind to DNA and RNA, we can predict how mutations affect binding --- a key building block for computational identification of disease-causing mutations.
Babak Alipanahi, Andrew Delong, Matthew T Weirauch and Brendan J Frey. Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning. Nature Biotechnology doi:/. Published online July 27 2015. [ DeepBind article ] [ DeepBind web page ]